GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2463822 | 1 | rs118049526 | chr11:62107508 | ASRGL1 | chr11:62104774-62160885:+ | -0.63 | -6.19 | 1.55E-8 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs2275426 | 1 | rs11810993 | chr1:46478793 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs12780845 | 1 | rs11813099 | chr10:17183451 | CUBN | chr10:16865966-17171816:- | 0.3 | 4.6 | 1.29E-5 | Homocysteine levels |
| THYM | cis | rs2251844 | 1 | rs11856184 | chr15:43919162 | ADAL | chr15:43622872-43646094:+ | -0.51 | -4.38 | 3.06E-5 | Tumor biomarkers |
| THYM | cis | rs8050907 | 1 | rs11862083 | chr16:4649720 | NMRAL1 | chr16:4511696-4526307:- | -0.36 | -4.17 | 6.75E-5 | Obesity-related traits |
| THYM | cis | rs7223966 | 1 | rs11871767 | chr17:61698723 | TCAM1P | chr17:61934376-61941738:+ | -0.51 | -4.14 | 7.54E-5 | Body mass index |
| THYM | cis | rs7246967 | 1 | rs11879853 | chr19:23029434 | ZNF492 | chr19:22817126-22850472:+ | 0.5 | 5.66 | 1.61E-7 | Bronchopulmonary dysplasia |
| THYM | cis | rs4803480 | 1 | rs11882144 | chr19:42072602 | CEACAM21 | chr19:42055886-42093196:+ | 0.69 | 8.89 | 3.89E-14 | Schizophrenia |
| THYM | cis | rs7246967 | 1 | rs11882498 | chr19:23060012 | ZNF492 | chr19:22817126-22850472:+ | -0.52 | -5.7 | 1.32E-7 | Bronchopulmonary dysplasia |
| THYM | cis | rs7565981 | 1 | rs11886530 | chr2:101426084 | PDCL3 | chr2:101179418-101193201:+ | 0.51 | 4.17 | 6.67E-5 | Creutzfeldt-Jakob disease (variant) |
| THYM | cis | rs9309473 | 1 | rs11893881 | chr2:73824373 | ALMS1P | chr2:73872046-73912692:+ | 0.61 | 4.95 | 3.2E-6 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs11899740 | chr2:73631212 | ALMS1P | chr2:73872046-73912692:+ | 0.66 | 4.79 | 6.16E-6 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs11899902 | chr2:73631564 | ALMS1P | chr2:73872046-73912692:+ | 0.62 | 4.72 | 8.01E-6 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs11901272 | chr2:73720444 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.75 | 7.12E-6 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs11903916 | chr2:73815328 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.7 | 8.77E-6 | Metabolite levels |